I don't even know what to make of this:
4041 patients show up and consent to be in a massive antidepressant trial, and almost 25% can't even score a HAM-D of 14? (7=complete cure.) Who are these people? What were they thinking?
And then of the ones who actually stay to participate (N=2876), their average HAM-D is 21? For two years?
And Celexa cures a third of these patients? Half of them in less than 6 weeks? After two years walking around HAM-D =21? Cures? Celexa? 40mg? Hello?
Remember, this is open label. These people, who presumably have been in psychiatric treatment for a long time (mean length of illness 15 years), know that they are taking 40mg of Celexa. Not a new experimental drug with a new mechanism of action. Celexa. 1/3rd get cured. After all this time.
BTW, the people who failed this Celexa study get moved into Star-D II. What is the relevance of this? Well, in this study 63% were female, 75% were white, 40% were married, 87% were high school grads or greater, 56% had jobs. It is the opposite of this demographic that is most likely not to have gotten better.